EP4 receptor stimulation down-regulates human eosinophil function
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چکیده
منابع مشابه
Mild hyperthermia down-regulates receptor-dependent neutrophil function.
Mild hypothermia impairs resistance to infection and, reportedly, impairs phagocytosis and oxidative killing of unopsonized bacteria. We evaluated various functions at 33 degrees-41 degrees C in neutrophils taken from volunteers. Adhesion on endothelial cells was determined using light microscopy. Adhesion molecule expression and receptors, phagocytosis, and release of reactive oxidants were as...
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Prostaglandins, particularly prostaglandin E2 (PGE2), play an important role during inflammation. This is exemplified by the clinical use of cyclooxygenase 2 inhibitors, which interfere with PGE2 synthesis, as effective antiinflammatory drugs. Here, we show that PGE2 directly promotes differentiation and proinflammatory functions of human and murine IL-17-producing T helper (Th17) cells. In hum...
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BACKGROUND Eosinophils are involved in various inflammatory processes including allergic inflammation during which angiogenesis has been documented. Angiogenesis is most likely connected to the hypoxia which characterizes inflamed tissues. Eosinophils produce VEGF and are pro-angiogenic. However, to the best of our knowledge no study has been performed to verify the existence of a direct link b...
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Th17 cells are implicated in host defence and autoimmune diseases. CD28/B7 co-stimulation is involved in the induction and progression of autoimmune diseases, but its role in controlling murine Th17 cell fate remains to be clarified. We here report that soluble anti-CD28 mAb suppressed the differentiation of anti-CD3-stimulated naïve CD4(+) T cells into IL-17-producing cells. CD28 co-stimulatio...
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Human vascular endothelial cells express the estrogen receptor-β (ER-β), which can be modulated by the opiate alkaloid morphine. OBJECTIVES: To determine if morphine is capable of down regulating the ER-β receptor in a similar fashion as the μ opiate receptor since they are both coupled to constitutive nitric oxide synthase derived nitric oxide release. METHODS AND RESULTS: Endothelial cells ob...
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ژورنال
عنوان ژورنال: Cellular and Molecular Life Sciences
سال: 2011
ISSN: 1420-682X,1420-9071
DOI: 10.1007/s00018-011-0642-5